Interleukin-6 receptor subunit beta

BE0010013ProteinHumansIL6ST

Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1 (PubMed:11285233, PubMed:11294841, PubMed:1542794,... It is acted on by 4 drugs in DrugBank.

Gene name
IL6ST
UniProtKB entry
P40189Swiss-Prot
Cellular location
Cell membrane
Residues / weight
918 residues · 103,536 Da
Also known as
CDw130 · gp130 · IL-6 receptor subunit beta · IL-6R subunit beta · IL-6R-beta

Resolves to

Protein
UniProtP40189UniProt nameIL6RB_HUMAN
Gene
HGNCHGNC:6021NCBI Gene3572GeneCardsIL6ST
Pharmacology
IUPHAR/GtoPdb2317KEGGhsa:3572
Structure
PDB1BJ8PDB1BQUPDB1I1R
Drugs

What you can answer from here — as of August 18, 2020

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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34GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-6 receptor subunit beta, how selective are they, and which programs against it are still in active trials?

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