Envelope glycoprotein

BE0010023ProteinZaire ebolavirus (strain Mayinga-76)GP

Envelope glycoprotein Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. It is acted on by 8 drugs in DrugBank.

Gene name
GP
UniProtKB entry
Q05320Swiss-Prot
Cellular location
Virion membrane
Residues / weight
676 residues · 74,464 Da
Also known as
GP · GP1,2

Resolves to

Protein
UniProtQ05320UniProt nameVGP_EBOZM
Gene
NCBI Gene911829
Pharmacology
KEGGvg:911829
Structure
PDB2EBOPDB2RLJPDB3CSY
Drugs

What you can answer from here — as of October 16, 2020

8DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Envelope glycoprotein, how selective are they, and which programs against it are still in active trials?

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