Sphingosine kinase 2

BE0010025ProteinHumansSPHK2

Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. It is acted on by 1 drug in DrugBank.

Gene name
SPHK2
UniProtKB entry
Q9NRA0Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
654 residues · 69,216 Da
Also known as
2.7.1.91 · SK 2 · SK2 · SPK 2

Resolves to

Protein
UniProtQ9NRA0UniProt nameSPHK2_HUMAN
Gene
HGNCHGNC:18859NCBI Gene56848GeneCardsSPHK2
Pharmacology
IUPHAR/GtoPdb2205KEGGhsa:56848
Drugs

What you can answer from here — as of December 04, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Sphingosine kinase 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In