Cytochrome P450 4F3

BE0010048ProteinHumansCYP4F3

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:11461919, PubMed:15145985, PubMed:16547005, PubMed:16820285, PubMed:18065749, PubMed:18182499, PubMed:18577768, PubMed:8486631, PubMed:9675028). It is acted on by 2 drugs in DrugBank.

Gene name
CYP4F3
UniProtKB entry
Q08477Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
520 residues · 59,846 Da
Also known as
1.14.14.1 · 20-HETE synthase · 20-hydroxyeicosatetraenoic acid synthase · CYPIVF3 · Cytochrome P450-LTB-omega

Resolves to

Protein
UniProtQ08477UniProt nameCP4F3_HUMAN
Gene
HGNCHGNC:2646NCBI Gene4051GeneCardsCYP4F3
Pharmacology
IUPHAR/GtoPdb1345KEGGhsa:4051
Drugs

What you can answer from here — as of March 22, 2021

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 4F3, how selective are they, and which programs against it are still in active trials?

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