3-ketoacyl-CoA thiolase, mitochondrial

BE0010052ProteinHumansACAA2

In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). It is acted on by 1 drug in DrugBank.

Gene name
ACAA2
UniProtKB entry
P42765Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
397 residues · 41,924 Da
Also known as
2.3.1.16 · Acetyl-CoA acetyltransferase · Acetyl-CoA acyltransferase · Acyl-CoA hydrolase, mitochondrial · Beta-ketothiolase

Resolves to

Protein
UniProtP42765UniProt nameTHIM_HUMAN
Gene
HGNCHGNC:83NCBI Gene10449GeneCardsACAA2
Pharmacology
KEGGhsa:10449
Structure
PDB4C2JPDB4C2K
Drugs

What you can answer from here — as of April 09, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-ketoacyl-CoA thiolase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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