P-selectin glycoprotein ligand 1

BE0010069ProteinHumansSELPLG

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. It is acted on by 1 drug in DrugBank.

Gene name
SELPLG
UniProtKB entry
Q14242Swiss-Prot
Cellular location
Membrane
Residues / weight
412 residues · 43,201 Da
Also known as
PSGL-1 · Selectin P ligand

Resolves to

Protein
UniProtQ14242UniProt nameSELPL_HUMAN
Gene
HGNCHGNC:10722NCBI Gene6404GeneCardsSELPLG
Pharmacology
KEGGhsa:6404
Structure
PDB1G1S
Drugs

What you can answer from here — as of June 09, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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24+ReferencesStructured and connected to the statements they support
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Which compounds in development act on P-selectin glycoprotein ligand 1, and which indications are they being tested in?

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