CD27 antigen

BE0010071ProteinHumansCD27

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863). It is acted on by 2 drugs in DrugBank.

Gene name
CD27
UniProtKB entry
P26842Swiss-Prot
Cellular location
Cell membrane
Residues / weight
260 residues · 29,137 Da
Also known as
CD27L receptor · T-cell activation antigen CD27 · T14 · TNFRSF7 · Tumor necrosis factor receptor superfamily member 7

Resolves to

Protein
UniProtP26842UniProt nameCD27_HUMAN
Gene
HGNCHGNC:11922NCBI Gene939GeneCardsCD27
Pharmacology
KEGGhsa:939
Structure
PDB5TL5PDB5TLJPDB5TLK
Drugs

What you can answer from here — as of July 30, 2021

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on CD27 antigen, and which indications are they being tested in?

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