C5a anaphylatoxin chemotactic receptor 1

BE0010095ProteinHumansC5AR1

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:36806352, PubMed:7622471, PubMed:8182049, PubMed:9553099). It is acted on by 4 drugs in DrugBank.

Gene name
C5AR1
UniProtKB entry
P21730Swiss-Prot
Cellular location
Cell membrane
Residues / weight
350 residues · 39,335 Da
Also known as
C5a anaphylatoxin chemotactic receptor · C5a-R · C5AR · C5R1

Resolves to

Protein
UniProtP21730UniProt nameC5AR1_HUMAN
Gene
HGNCHGNC:1338NCBI Gene728GeneCardsC5AR1
Pharmacology
IUPHAR/GtoPdb32KEGGhsa:728
Structure
PDB2K3UPDB5O9HPDB6C1Q
Drugs

What you can answer from here — as of October 12, 2021

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C5a anaphylatoxin chemotactic receptor 1, how selective are they, and which programs against it are still in active trials?

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