Histone acetyltransferase p300

BE0010118ProteinHumansEP300

Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:40240600, PubMed:8945521). It is acted on by 2 drugs in DrugBank.

Gene name
EP300
UniProtKB entry
Q09472Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
2,414 residues · 264,160 Da
Also known as
2.3.1.48 · E1A-associated protein p300 · Histone butyryltransferase p300 · Histone crotonyltransferase p300 · P300

Resolves to

Protein
UniProtQ09472UniProt nameEP300_HUMAN
Gene
HGNCHGNC:3373NCBI Gene2033GeneCardsEP300
Pharmacology
IUPHAR/GtoPdb2735KEGGhsa:2033
Structure
PDB1L3EPDB1P4QPDB2K8F
Drugs

What you can answer from here — as of November 08, 2021

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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122+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histone acetyltransferase p300, and which indications are they being tested in?

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