Apoptosis regulator BAX

BE0010137ProteinHumansBAX

Plays a role in the mitochondrial apoptotic process (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:36361894, PubMed:8358790, PubMed:8521816). It is acted on by 2 drugs in DrugBank.

Gene name
BAX
UniProtKB entry
Q07812Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
192 residues · 21,184 Da
Also known as
Bcl-2-like protein 4 · Bcl2-L-4 · BCL2L4

Resolves to

Protein
UniProtQ07812UniProt nameBAX_HUMAN
Gene
HGNCHGNC:959NCBI Gene581GeneCardsBAX
Pharmacology
KEGGhsa:581
Structure
PDB1F16PDB2G5BPDB2K7W
Drugs

What you can answer from here — as of November 16, 2021

2DrugsApproved to experimental, with action, bond type and pharmacological action
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20Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Apoptosis regulator BAX, and which indications are they being tested in?

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