Cytochrome P450 7B1

BE0010148ProteinHumansCYP7B1

A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). It is acted on by 1 drug in DrugBank.

Gene name
CYP7B1
UniProtKB entry
O75881Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
506 residues · 58,255 Da
Also known as
24-hydroxycholesterol 7-alpha-hydroxylase · 25/26-hydroxycholesterol 7-alpha-hydroxylase · 3-hydroxysteroid 7-alpha hydroxylase · Oxysterol 7-alpha-hydroxylase

Resolves to

Protein
UniProtO75881UniProt nameCP7B1_HUMAN
Gene
HGNCHGNC:2652NCBI Gene9420GeneCardsCYP7B1
Pharmacology
KEGGhsa:9420
Drugs

What you can answer from here — as of December 02, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cytochrome P450 7B1, and which indications are they being tested in?

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