Cytochrome P450 7A1

BE0010183ProteinHumansCYP7A1

A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643, PubMed:2384150). It is acted on by 2 drugs in DrugBank.

Gene name
CYP7A1
UniProtKB entry
P22680Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
504 residues · 57,660 Da
Also known as
24-hydroxycholesterol 7-alpha-hydroxylase · Cholesterol 7-alpha-hydroxylase · Cholesterol 7-alpha-monooxygenase · CYP7 · CYPVII

Resolves to

Protein
UniProtP22680UniProt nameCP7A1_HUMAN
Gene
HGNCHGNC:2651NCBI Gene1581GeneCardsCYP7A1
Pharmacology
IUPHAR/GtoPdb1354KEGGhsa:1581
Structure
PDB3DAXPDB3SN5PDB3V8D
Drugs

What you can answer from here — as of January 05, 2022

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
17GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cytochrome P450 7A1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In