Melanocyte protein PMEL

BE0010187ProteinHumansPMEL

Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. It is acted on by 3 drugs in DrugBank.

Gene name
PMEL
UniProtKB entry
P40967Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
661 residues · 70,255 Da
Also known as
D12S53E · ME20-M · ME20M · Melanocyte protein Pmel 17 · Melanocytes lineage-specific antigen GP100

Resolves to

Protein
UniProtP40967UniProt namePMEL_HUMAN
Gene
HGNCHGNC:10880NCBI Gene6490GeneCardsPMEL
Pharmacology
KEGGhsa:6490
Structure
PDB1TVBPDB1TVHPDB3CC5
Drugs

What you can answer from here — as of January 26, 2022

3DrugsApproved to experimental, with action, bond type and pharmacological action
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40Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Melanocyte protein PMEL, how selective are they, and which programs against it are still in active trials?

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