Interleukin-1 receptor-like 2

Details

Name
Interleukin-1 receptor-like 2
Kind
protein
Synonyms
  • 3.2.2.6
  • IL-1Rrp2
  • IL-36 receptor
  • IL-36R
  • IL1R-rp2
  • IL1RRP2
  • Interleukin-1 receptor-related protein 2
Gene Name
IL1RL2
UniProtKB Entry
Q9HB29Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052791|Interleukin-1 receptor-like 2
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNS
SKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDT
SIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRL
LVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQ
LGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNI
TFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFK
IDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYK
LFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDG
MKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRR
CRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG
Number of residues
575
Molecular Weight
65404.06
Theoretical pI
Not Available
GO Classification
Functions
NAD+ nucleosidase activity
General Function
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway
Specific Function
interleukin-1 receptor activity
Pfam Domain Function
Signal Regions
1-19
Transmembrane Regions
336-356
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0052792|Interleukin-1 receptor-like 2 (IL1RL2)
ATGTGGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGAT
GGATGCAAGGACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTT
AATTGTACATTCCCTCCCATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCT
AGCAAAATCCCAGTGTCCAAAATCATACAGTCTAGAATTCACCAGGACGAGACTTGGATT
TTGTTTCTCCCCATGGAATGGGGGGACTCAGGAGTCTACCAATGTGTTATAAAGGGTAGA
GACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAAAAACATTGGTGTGACACT
TCCATAGGTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACATCTTGGAAAA
GATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAAAG
TGGTATAAGGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTT
TTGGTGAGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACA
CACTCAGGGAAGCAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTACAGAAAGAGCT
GGATATGGAGGAAGTGTCCCTAAAATCATTTATCCAAAAAATCATTCAATTGAAGTACAG
CTTGGTACCACTCTGATTGTGGACTGCAATGTAACAGACACCAAGGATAATACAAATCTA
CGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGATGAATCCAAACGAATC
AGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGTAAACATC
ACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTG
TCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGA
GGGCTTATCGCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAG
ATCGACATTGTTCTTTGGTATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGG
AAGCTGTATGACGCCTATGTCTTATACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCC
GTGGATGCCCTGGTGTTGAATATCCTGCCCGAGGTGTTGGAGAGACAATGTGGATATAAG
TTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGTGGCCAATGTCATCGATGAA
AACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGCTGGGCTTTGGC
CTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGACGGG
ATGAAGGTTATTCTCATTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCA
ATTCAGTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAG
TCACAGTGTATGAAGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCGCCCAGAAGG
TGTCGGCCGTTTCCTCCGGTCCAGCTGCTGCAGCACACACCTTGCTACCGCACCGCAGGC
CCAGAACTAGGCTCAAGAAGAAAGAAGTGTACTCTCACGACTGGCTAA
Chromosome Location
2
Locus
2q12.1
External Identifiers
ResourceLink
UniProtKB IDQ9HB29
UniProtKB Entry NameILRL2_HUMAN
GeneCard IDIL1RL2
HGNC IDHGNC:5999
PDB ID(s)6U6U
KEGG IDhsa:8808
IUPHAR/Guide To Pharmacology ID1736
NCBI Gene ID8808
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Spesolimabapproved, investigationalyestargetantagonistDetails