Growth arrest-specific protein 6

BE0010201ProteinHumansGAS6

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. It is acted on by 1 drug in DrugBank.

Gene name
GAS6
UniProtKB entry
Q14393Swiss-Prot
Cellular location
Secreted
Residues / weight
678 residues · 74,925 Da
Also known as
AXL receptor tyrosine kinase ligand · AXLLG · GAS-6

Resolves to

Protein
UniProtQ14393UniProt nameGAS6_HUMAN
Gene
HGNCHGNC:4168NCBI Gene2621GeneCardsGAS6
Pharmacology
KEGGhsa:2621
Structure
PDB1H30PDB2C5DPDB4RA0
Drugs

What you can answer from here — as of October 13, 2022

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Growth arrest-specific protein 6, and which indications are they being tested in?

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