ATP synthase subunit epsilon, mitochondrial
Details
- Name
- ATP synthase subunit epsilon, mitochondrial
- Kind
- protein
- Synonyms
- ATP synthase F1 subunit epsilon
- ATP5E
- ATPase subunit epsilon
- Gene Name
- ATP5F1E
- UniProtKB Entry
- P56381Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052804|ATP synthase subunit epsilon, mitochondrial MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAEKTSGSNVKIVKVKKE
- Number of residues
- 51
- Molecular Weight
- 5779.72
- Theoretical pI
- Not Available
- GO Classification
- Componentsmitochondrion / proton-transporting ATP synthase complex
- General Function
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity)
- Specific Function
- hydrolase activity
- Pfam Domain Function
- ATP-synt_Eps (PF04627)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0052805|ATP synthase subunit epsilon, mitochondrial (ATP5F1E) ATGGTGGCCTACTGGAGACAGGCTGGACTCAGCTACATCCGATACTCCCAGATCTGTGCA AAAGCAGTGAGAGATGCACTGAAGACAGAATTCAAAGCAAATGCTGAGAAGACTTCTGGC AGCAACGTAAAAATTGTGAAAGTAAAGAAGGAATAA
- Chromosome Location
- 20
- Locus
- 20q13.32
- External Identifiers
Resource Link UniProtKB ID P56381 UniProtKB Entry Name ATP5E_HUMAN GeneCard ID ATP5F1E HGNC ID HGNC:838 PDB ID(s) 8H9F, 8H9J, 8H9M, 8H9Q, 8H9S, 8H9T, 8H9U, 8H9V, 8KHF, 8KI3 KEGG ID hsa:514 NCBI Gene ID 514 - General References
- Not Available
Associated Data
- Drug Relations
- Not Available