Guanine deaminase

BE0010217ProteinHumansGDA

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. It is acted on by 1 drug in DrugBank.

Gene name
GDA
UniProtKB entry
Q9Y2T3Swiss-Prot
Residues / weight
454 residues · 51,003 Da
Also known as
3.5.4.3 · GAH · Guanase · Guanine aminase · Guanine aminohydrolase

Resolves to

Protein
UniProtQ9Y2T3UniProt nameGUAD_HUMAN
Gene
HGNCHGNC:4212NCBI Gene9615GeneCardsGDA
Pharmacology
KEGGhsa:9615
Structure
PDB2UZ9PDB3E0LPDB4AQL
Drugs

What you can answer from here — as of April 13, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Guanine deaminase, and which indications are they being tested in?

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