Thymidine kinase
Details
- Name
- Thymidine kinase
- Kind
- protein
- Synonyms
- 2.7.1.21
- Gene Name
- TK
- UniProtKB Entry
- P17402Swiss-Prot
- Organism
- Human herpesvirus 1 (strain KOS)
- NCBI Taxonomy ID
- 10306
- Amino acid sequence
>lcl|BSEQ0052818|Thymidine kinase MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT ICDLARMFAREMGEAN
- Number of residues
- 376
- Molecular Weight
- 40926.565
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / thymidine kinase activityProcessesDNA biosynthetic process / phosphorylation / TMP biosynthetic process
- General Function
- Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
- Specific Function
- ATP binding
- Pfam Domain Function
- Herpes_TK (PF00693)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P17402 UniProtKB Entry Name KITH_HHV1K - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-9-(2-hydroxypropyl)adenine experimental unknown target inducer Details