HLA class II histocompatibility antigen gamma chain

BE0010224ProteinHumansCD74

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to... It is acted on by 3 drugs in DrugBank.

Gene name
CD74
UniProtKB entry
P04233Swiss-Prot
Cellular location
Cell membrane
Residues / weight
296 residues · 33,515 Da
Also known as
DHLAG · HLA-DR antigens-associated invariant chain · Ia antigen-associated invariant chain · Ii

Resolves to

Protein
UniProtP04233UniProt nameHG2A_HUMAN
Gene
HGNCHGNC:1697NCBI Gene972GeneCardsCD74
Pharmacology
IUPHAR/GtoPdb2840KEGGhsa:972
Structure
PDB1A6APDB1ICFPDB1IIE
Drugs

What you can answer from here — as of June 15, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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71GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on HLA class II histocompatibility antigen gamma chain, and which indications are they being tested in?

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