Cell adhesion molecule CEACAM3

BE0010234ProteinHumansCEACAM3

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. It is acted on by 1 drug in DrugBank.

Gene name
CEACAM3
UniProtKB entry
P40198Swiss-Prot
Cellular location
Membrane
Residues / weight
252 residues · 27,091 Da
Also known as
Carcinoembryonic antigen CGM1 · Carcinoembryonic antigen-related cell adhesion molecule 3 · CD66D · CEA cell adhesion molecule 3 · CGM1

Resolves to

Protein
UniProtP40198UniProt nameCEAM3_HUMAN
Gene
HGNCHGNC:1815NCBI Gene1084GeneCardsCEACAM3
Pharmacology
KEGGhsa:1084
Structure
PDB6AVZPDB6AW0PDB6AW1
Drugs

What you can answer from here — as of December 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Cell adhesion molecule CEACAM3, and which indications are they being tested in?

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