Platelet-derived growth factor subunit A
Details
- Name
- Platelet-derived growth factor subunit A
- Kind
- protein
- Synonyms
- PDGF subunit A
- PDGF-1
- PDGF1
- Platelet-derived growth factor A chain
- Platelet-derived growth factor alpha polypeptide
- Gene Name
- PDGFA
- UniProtKB Entry
- P04085Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052854|Platelet-derived growth factor subunit A MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA TTSLNPDYREEDTGRPRESGKKRKRKRLKPT
- Number of residues
- 211
- Molecular Weight
- 24042.68
- Theoretical pI
- Not Available
- GO Classification
- Processespositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- General Function
- Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)
- Specific Function
- Collagen binding
- Pfam Domain Function
- Signal Regions
- 1-20
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052855|Platelet-derived growth factor subunit A (PDGFA) ATGAGGACCTTGGCTTGCCTGCTGCTCCTCGGCTGCGGATACCTCGCCCATGTTCTGGCC GAGGAAGCCGAGATCCCCCGCGAGGTGATCGAGAGGCTGGCCCGCAGTCAGATCCACAGC ATCCGGGACCTCCAGCGACTCCTGGAGATAGACTCCGTAGGGAGTGAGGATTCTTTGGAC ACCAGCCTGAGAGCTCACGGGGTCCATGCCACTAAGCATGTGCCCGAGAAGCGGCCCCTG CCCATTCGGAGGAAGAGAAGCATCGAGGAAGCTGTCCCCGCTGTCTGCAAGACCAGGACG GTCATTTACGAGATTCCTCGGAGTCAGGTCGACCCCACGTCCGCCAACTTCCTGATCTGG CCCCCGTGCGTGGAGGTGAAACGCTGCACCGGCTGCTGCAACACGAGCAGTGTCAAGTGC CAGCCCTCCCGCGTCCACCACCGCAGCGTCAAGGTGGCCAAGGTGGAATACGTCAGGAAG AAGCCAAAATTAAAAGAAGTCCAGGTGAGGTTAGAGGAGCATTTGGAGTGCGCCTGCGCG ACCACAAGCCTGAATCCGGATTATCGGGAAGAGGACACGGGAAGGCCTAGGGAGTCAGGT AAAAAACGGAAAAGAAAAAGGTTAAAACCCACCTAA
- Chromosome Location
- 7
- Locus
- 7p22.3
- External Identifiers
Resource Link UniProtKB ID P04085 UniProtKB Entry Name PDGFA_HUMAN GeneCard ID PDGFA HGNC ID HGNC:8799 PDB ID(s) 3MJK KEGG ID hsa:5154 NCBI Gene ID 5154 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Squalamine investigational yes target inhibitor Details