G protein-coupled receptor family C group 5 member D

BE0010290ProteinHumansGPRC5D

G protein-coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails. It is acted on by 4 drugs in DrugBank.

Gene name
GPRC5D
UniProtKB entry
Q9NZD1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
345 residues · 38,791 Da

Resolves to

Protein
UniProtQ9NZD1UniProt nameGPC5D_HUMAN
Gene
HGNCHGNC:13310NCBI Gene55507GeneCardsGPRC5D
Pharmacology
KEGGhsa:55507
Structure
PDB8YZKPDB9IMA
Drugs

What you can answer from here — as of June 19, 2026

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled receptor family C group 5 member D, how selective are they, and which programs against it are still in active trials?

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