Aryl hydrocarbon receptor nuclear translocator

BE0010296ProteinHumansARNT

Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. It is acted on by 1 drug in DrugBank.

Gene name
ARNT
UniProtKB entry
P27540Swiss-Prot
Cellular location
Nucleus
Residues / weight
789 residues · 86,636 Da
Also known as
ARNT protein · BHLHE2 · Class E basic helix-loop-helix protein 2 · Dioxin receptor, nuclear translocator · HIF-1-beta

Resolves to

Protein
UniProtP27540UniProt nameARNT_HUMAN
Gene
HGNCHGNC:700NCBI Gene405GeneCardsARNT
Pharmacology
KEGGhsa:405
Structure
PDB1X0OPDB2A24PDB2B02
Drugs

What you can answer from here — as of October 23, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aryl hydrocarbon receptor nuclear translocator, and which indications are they being tested in?

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