Autotaxin

BE0010333ProteinHumansENPP2

Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:14500380, PubMed:15769751, PubMed:26371182, PubMed:27754931). It is acted on by 4 drugs in DrugBank.

Gene name
ENPP2
UniProtKB entry
Q13822Swiss-Prot
Cellular location
Secreted
Residues / weight
863 residues · 98,993 Da
Also known as
3.1.4.39 · 3.1.4.4 · ATX · E-NPP 2 · Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Resolves to

Protein
UniProtQ13822UniProt nameENPP2_HUMAN
Gene
HGNCHGNC:3357NCBI Gene5168GeneCardsENPP2
Pharmacology
IUPHAR/GtoPdb2901KEGGhsa:5168
Structure
PDB4ZG6PDB4ZG7PDB4ZG9
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Autotaxin, and which indications are they being tested in?

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