Transcriptional coactivator YAP1

BE0010338ProteinHumansYAP1

Transcriptional regulator with dual roles as a coactivator and corepressor. It is acted on by 3 drugs in DrugBank.

Gene name
YAP1
UniProtKB entry
P46937Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
504 residues · 54,461 Da
Also known as
Protein yorkie homolog · YAP65 · Yes-associated protein 1 · Yes-associated protein YAP65 homolog

Resolves to

Protein
UniProtP46937UniProt nameYAP1_HUMAN
Gene
HGNCHGNC:16262NCBI Gene10413GeneCardsYAP1
Pharmacology
KEGGhsa:10413
Structure
PDB1JMQPDB1K5RPDB1K9Q
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transcriptional coactivator YAP1, how selective are they, and which programs against it are still in active trials?

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