Interleukin-18

BE0010340ProteinHumansIL18

Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). It is acted on by 3 drugs in DrugBank.

Gene name
IL18
UniProtKB entry
Q14116Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
193 residues · 22,326 Da
Also known as
Iboctadekin · IFN-gamma-inducing factor · IGIF · IL-1 gamma · IL-18

Resolves to

Protein
UniProtQ14116UniProt nameIL18_HUMAN
Gene
HGNCHGNC:5986NCBI Gene3606GeneCardsIL18
Pharmacology
KEGGhsa:3606
Structure
PDB1J0SPDB2VXTPDB3F62
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interleukin-18, and which indications are they being tested in?

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