Pro-glucagon
Details
- Name
- Pro-glucagon
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- GCG
- UniProtKB Entry
- P01275Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052980|Pro-glucagon MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
- Number of residues
- 180
- Molecular Weight
- 20909.025
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes
- Specific Function
- Glucagon receptor binding
- Pfam Domain Function
- Hormone_2 (PF00123)
- Signal Regions
- 1-20
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052981|Pro-glucagon (GCG) ATGAAAAGCATTTACTTTGTGGCTGGATTATTTGTAATGCTGGTACAAGGCAGCTGGCAA CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA TAA
- Chromosome Location
- 2
- Locus
- 2q24.2
- External Identifiers
Resource Link UniProtKB ID P01275 UniProtKB Entry Name GLUC_HUMAN GeneCard ID GCG HGNC ID HGNC:4191 PDB ID(s) 1BH0, 1D0R, 1NAU, 2G49, 2L63, 2L64, 2M5P, 2M5Q, 3IOL, 4APD, 4ZGM, 5OTU, 5OTV, 5OTW, 5OTX, 5VAI, 5YQZ, 6EDS, 6LMK, 6LML, 6NZN, 6PHI, 6PHJ, 6PHK, 6PHL, 6PHO, 6PHP, 6VCB, 6X18, 7D68, 7DUQ, 7KI0, 7KI1, 7XM8, 8ANJ, 8ANK, 8JRV KEGG ID hsa:2641 NCBI Gene ID 2641 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cotadutide investigational yes target agonist Details