NPC intracellular cholesterol transporter 2

BE0010359ProteinHumansNPC2

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). It is acted on by 1 drug in DrugBank.

Gene name
NPC2
UniProtKB entry
P61916Swiss-Prot
Cellular location
Secreted
Residues / weight
151 residues · 16,570 Da
Also known as
Epididymal secretory protein E1 · HE1 · Human epididymis-specific protein 1 · Niemann-Pick disease type C2 protein

Resolves to

Protein
UniProtP61916UniProt nameNPC2_HUMAN
Gene
HGNCHGNC:14537NCBI Gene10577GeneCardsNPC2
Pharmacology
KEGGhsa:10577
Structure
PDB5KWYPDB6W5V
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on NPC intracellular cholesterol transporter 2, how selective are they, and which programs against it are still in active trials?

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