Protransforming growth factor alpha

BE0010380ProteinHumansTGFA

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. It is acted on by 1 drug in DrugBank.

Gene name
TGFA
UniProtKB entry
P01135Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
160 residues · 17,006 Da

Resolves to

Protein
UniProtP01135UniProt nameTGFA_HUMAN
Gene
HGNCHGNC:11765NCBI Gene7039GeneCardsTGFA
Pharmacology
KEGGhsa:7039
Structure
PDB1GK5PDB1MOXPDB1YUF
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protransforming growth factor alpha, and which indications are they being tested in?

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