RNA-binding protein FUS

BE0010383ProteinHumansFUS

DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). It is acted on by 1 drug in DrugBank.

Gene name
FUS
UniProtKB entry
P35637Swiss-Prot
Cellular location
Nucleus
Residues / weight
526 residues · 53,426 Da
Also known as
75 kDa DNA-pairing protein · Oncogene FUS · Oncogene TLS · POMp75 · TLS

Resolves to

Protein
UniProtP35637UniProt nameFUS_HUMAN
Gene
HGNCHGNC:4010NCBI Gene2521GeneCardsFUS
Pharmacology
KEGGhsa:2521
Structure
PDB2LA6PDB2LCWPDB4FDD
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on RNA-binding protein FUS, and which indications are they being tested in?

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