Survival motor neuron protein

BE0010390ProteinHumansSMN1

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). It is acted on by 2 drugs in DrugBank.

Gene name
SMN1
UniProtKB entry
Q16637Swiss-Prot
Cellular location
Nucleus, gem
Residues / weight
294 residues · 31,848 Da
Also known as
Component of gems 1 · Gemin-1 · SMN · SMNC · SMNT

Resolves to

Protein
UniProtQ16637UniProt nameSMN_HUMAN
Gene
HGNCHGNC:11118NCBI Gene6607GeneCardsSMN2
Pharmacology
KEGGhsa:6607
Structure
PDB1G5VPDB1MHNPDB2LEH
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Survival motor neuron protein, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In