Transcription activator GLI1

BE0010393ProteinHumansGLI1

Transcription activator that acts as a key effector of the smoothened signaling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal... It is acted on by 2 drugs in DrugBank.

Gene name
GLI1
UniProtKB entry
P08151Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,106 residues · 117,904 Da
Also known as
GLI · Glioma-associated oncogene · Oncogene GLI

Resolves to

Protein
UniProtP08151UniProt nameGLI1_HUMAN
Gene
HGNCHGNC:4317NCBI Gene2735GeneCardsGLI1
Pharmacology
KEGGhsa:2735
Structure
PDB2GLIPDB4BLBPDB4KMD
Drugs

What you can answer from here — as of June 19, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Transcription activator GLI1, and which indications are they being tested in?

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