SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

BE0010396ProteinHumansSMARCA4

ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). It is acted on by 1 drug in DrugBank.

Gene name: SMARCA4
UniProtKB entry: P51532Swiss-Prot
Cellular location: Nucleus
Residues / weight: 1,647 residues · 184,644 Da
Also known as: 3.6.4.- · BAF190A · BRG1 · BRG1-associated factor 190A · Mitotic growth and transcription activator

Resolves to

Protein

UniProtP51532UniProt nameSMCA4_HUMAN

Gene

HGNCHGNC:11100NCBI Gene6597GeneCardsSMARCA4

Pharmacology

IUPHAR/GtoPdb2740KEGGhsa:6597

Structure

PDB2GRCPDB2H60PDB3UVD

Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action

5Clinical trialsTrials of drugs acting on it, by phase and status

13GO termsFunction, process and component, as structured annotations

7Pfam domainsDomain architecture mapped to Pfam families and clans

3+ReferencesStructured and connected to the statements they support

Which compounds in development act on SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, and which indications are they being tested in?

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