Serine/threonine-protein kinase STK11

BE0010411ProteinHumansSTK11

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response (PubMed:12805220, PubMed:14517248,... It is acted on by 2 drugs in DrugBank.

Gene name
STK11
UniProtKB entry
Q15831Swiss-Prot
Cellular location
Nucleus
Residues / weight
433 residues · 48,635 Da
Also known as
2.7.11.1 · hLKB1 · Liver kinase B1 · LKB1 · PJS

Resolves to

Protein
UniProtQ15831UniProt nameSTK11_HUMAN
Gene
HGNCHGNC:11389NCBI Gene6794GeneCardsSTK11
Pharmacology
KEGGhsa:6794
Structure
PDB2WTKPDB4ZDRPDB5WXN
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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42GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein kinase STK11, and which indications are they being tested in?

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