Integrin alpha-M

BE0010412ProteinHumansITGAM

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is acted on by 3 drugs in DrugBank.

Gene name
ITGAM
UniProtKB entry
P11215Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,152 residues · 127,178 Da
Also known as
CD11 antigen-like family member B · CD11B · Cell surface glycoprotein MAC-1 subunit alpha · CR-3 alpha chain · CR3A

Resolves to

Protein
UniProtP11215UniProt nameITAM_HUMAN
Gene
HGNCHGNC:6149NCBI Gene3684GeneCardsITGAM
Pharmacology
KEGGhsa:3684
Structure
PDB1BHOPDB1BHQPDB1IDN
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
6Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
6+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Integrin alpha-M, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In