NKG2-D type II integral membrane protein

BE0010415ProteinHumansKLRK1

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It is acted on by 1 drug in DrugBank.

Gene name
KLRK1
UniProtKB entry
P26718Swiss-Prot
Cellular location
Cell membrane
Residues / weight
216 residues · 25,304 Da
Also known as
D12S2489E · Killer cell lectin-like receptor subfamily K member 1 · NK cell receptor D · NKG2-D-activating NK receptor · NKG2D

Resolves to

Protein
UniProtP26718UniProt nameNKG2D_HUMAN
Gene
HGNCHGNC:18788NCBI Gene22914GeneCardsKLRK1
Pharmacology
KEGGhsa:22914
Structure
PDB1HYRPDB1KCGPDB1MPU
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NKG2-D type II integral membrane protein, and which indications are they being tested in?

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