Runt-related transcription factor 1

BE0010423ProteinHumansRUNX1

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. It is acted on by 1 drug in DrugBank.

Gene name
RUNX1
UniProtKB entry
Q01196Swiss-Prot
Cellular location
Nucleus
Residues / weight
453 residues · 48,736 Da
Also known as
Acute myeloid leukemia 1 protein · AML1 · CBF-alpha-2 · CBFA2 · Core-binding factor subunit alpha-2

Resolves to

Protein
UniProtQ01196UniProt nameRUNX1_HUMAN
Gene
HGNCHGNC:10471NCBI Gene861GeneCardsRUNX1
Pharmacology
KEGGhsa:861
Structure
PDB1CMOPDB1CO1PDB1E50
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Runt-related transcription factor 1, and which indications are they being tested in?

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