Melanoma-associated antigen 3

BE0010446ProteinHumansMAGEA3

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:20864041, PubMed:31267705). It is acted on by 2 drugs in DrugBank.

Gene name
MAGEA3
UniProtKB entry
P43357Swiss-Prot
Residues / weight
314 residues · 34,747 Da
Also known as
Antigen MZ2-D · Cancer/testis antigen 1.3 · CT1.3 · MAGE-3 antigen · MAGE3

Resolves to

Protein
UniProtP43357UniProt nameMAGA3_HUMAN
Gene
HGNCHGNC:6801NCBI Gene4102GeneCardsMAGEA3
Pharmacology
KEGGhsa:4102
Structure
PDB1QEWPDB4V0PPDB5BRZ
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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22Clinical trialsTrials of drugs acting on it, by phase and status
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Melanoma-associated antigen 3, and which indications are they being tested in?

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