Fumarate hydratase, mitochondrial

BE0010459ProteinHumansFH

Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). It is acted on by 1 drug in DrugBank.

Gene name
FH
UniProtKB entry
P07954Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
510 residues · 54,637 Da
Also known as
4.2.1.2 · Fumarase · HsFH

Resolves to

Protein
UniProtP07954UniProt nameFUMH_HUMAN
Gene
HGNCHGNC:3700NCBI Gene2271GeneCardsFH
Pharmacology
KEGGhsa:2271
Structure
PDB3E04PDB5D6BPDB5UPP
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Fumarate hydratase, mitochondrial, and which indications are they being tested in?

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