Tumor necrosis factor ligand superfamily member 10
Details
- Name
- Tumor necrosis factor ligand superfamily member 10
- Kind
- protein
- Synonyms
- Apo-2 ligand
- Apo-2L
- APO2L
- Protein TRAIL
- TNF-related apoptosis-inducing ligand
- TRAIL
- Gene Name
- TNFSF10
- UniProtKB Entry
- P50591Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053281|Tumor necrosis factor ligand superfamily member 10 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
- Number of residues
- 281
- Molecular Weight
- 32508.69
- Theoretical pI
- Not Available
- GO Classification
- Processespositive regulation of canonical NF-kappaB signal transduction
- General Function
- Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
- Specific Function
- Cytokine activity
- Pfam Domain Function
- TNF (PF00229)
- Signal Regions
- Not Available
- Transmembrane Regions
- 18-38
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0053282|Tumor necrosis factor ligand superfamily member 10 (TNFSF10) ATGGCTATGATGGAGGTCCAGGGGGGACCCAGCCTGGGACAGACCTGCGTGCTGATCGTG ATCTTCACAGTGCTCCTGCAGTCTCTCTGTGTGGCTGTAACTTACGTGTACTTTACCAAC GAGCTGAAGCAGATGCAGGACAAGTACTCCAAAAGTGGCATTGCTTGTTTCTTAAAAGAA GATGACAGTTATTGGGACCCCAATGACGAAGAGAGTATGAACAGCCCCTGCTGGCAAGTC AAGTGGCAACTCCGTCAGCTCGTTAGAAAGATGATTTTGAGAACCTCTGAGGAAACCATT TCTACAGTTCAAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAG AGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAAC TCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGG CATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGG TTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACA AAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATA TTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTAT TCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTA ACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTTAGTT GGCTAA
- Chromosome Location
- 3
- Locus
- 3q26.31
- External Identifiers
Resource Link UniProtKB ID P50591 UniProtKB Entry Name TNF10_HUMAN GeneCard ID TNFSF10 HGNC ID HGNC:11925 PDB ID(s) 1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90, 5CIR KEGG ID hsa:8743 NCBI Gene ID 8743 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nimesulide approved, investigational, withdrawn yes target modulator Details