Tumor necrosis factor ligand superfamily member 10

BE0010497ProteinHumansTNFSF10

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). It is acted on by 2 drugs in DrugBank.

Gene name
TNFSF10
UniProtKB entry
P50591Swiss-Prot
Cellular location
Cell membrane
Residues / weight
281 residues · 32,509 Da
Also known as
Apo-2 ligand · Apo-2L · APO2L · Protein TRAIL · TNF-related apoptosis-inducing ligand

Resolves to

Protein
UniProtP50591UniProt nameTNF10_HUMAN
Gene
HGNCHGNC:11925NCBI Gene8743GeneCardsTNFSF10
Pharmacology
KEGGhsa:8743
Structure
PDB1D0GPDB1D2QPDB1D4V
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor ligand superfamily member 10, how selective are they, and which programs against it are still in active trials?

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