Tumor necrosis factor ligand superfamily member 6

BE0010499ProteinHumansFASLG

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). It is acted on by 1 drug in DrugBank.

Gene name
FASLG
UniProtKB entry
P48023Swiss-Prot
Cellular location
Cell membrane
Residues / weight
281 residues · 31,485 Da
Also known as
Apoptosis antigen ligand · APT1LG1 · APTL · CD95 ligand · CD95-L

Resolves to

Protein
UniProtP48023UniProt nameTNFL6_HUMAN
Gene
HGNCHGNC:11936NCBI Gene356GeneCardsFASLG
Pharmacology
KEGGhsa:356
Structure
PDB4MSVPDB5L19PDB5L36
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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36GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tumor necrosis factor ligand superfamily member 6, and which indications are they being tested in?

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