Macrophage colony-stimulating factor 1

BE0010511ProteinHumansCSF1

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. It is acted on by 2 drugs in DrugBank.

Gene name
CSF1
UniProtKB entry
P09603Swiss-Prot
Cellular location
Cell membrane
Residues / weight
554 residues · 60,179 Da
Also known as
CSF-1 · Lanimostim · M-CSF · MCSF · PG-M-CSF

Resolves to

Protein
UniProtP09603UniProt nameCSF1_HUMAN
Gene
HGNCHGNC:2432NCBI Gene1435GeneCardsCSF1
Pharmacology
KEGGhsa:1435
Structure
PDB1HMCPDB3UEZPDB3UF2
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Macrophage colony-stimulating factor 1, and which indications are they being tested in?

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