Activin receptor type-2B

BE0010524ProteinHumansACVR2B

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). It is acted on by 2 drugs in DrugBank.

Gene name
ACVR2B
UniProtKB entry
Q13705Swiss-Prot
Cellular location
Cell membrane
Residues / weight
512 residues · 57,723 Da
Also known as
2.7.11.30 · Activin receptor type IIB · ACTR-IIB

Resolves to

Protein
UniProtQ13705UniProt nameAVR2B_HUMAN
Gene
HGNCHGNC:174NCBI Gene93GeneCardsACVR2B
Pharmacology
IUPHAR/GtoPdb1792KEGGhsa:93
Structure
PDB2H62PDB2QLUPDB4FAO
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Activin receptor type-2B, how selective are they, and which programs against it are still in active trials?

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