Nibrin

BE0010536ProteinHumansNBN

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). It is acted on by 1 drug in DrugBank.

Gene name
NBN
UniProtKB entry
O60934Swiss-Prot
Cellular location
Nucleus
Residues / weight
754 residues · 84,958 Da
Also known as
Cell cycle regulatory protein p95 · hNbs1 · NBS · NBS1 · Nijmegen breakage syndrome protein 1

Resolves to

Protein
UniProtO60934UniProt nameNBN_HUMAN
Gene
HGNCHGNC:7652NCBI Gene4683GeneCardsNBN
Pharmacology
KEGGhsa:4683
Structure
PDB5WQDPDB7SIDPDB8BAH
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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33GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Nibrin, and which indications are they being tested in?

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