Tumor necrosis factor receptor superfamily member 10A

BE0010564ProteinHumansTNFRSF10A

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). It is acted on by 3 drugs in DrugBank.

Gene name
TNFRSF10A
UniProtKB entry
O00220Swiss-Prot
Cellular location
Cell membrane
Residues / weight
468 residues · 50,089 Da
Also known as
APO2 · Death receptor 4 · DR4 · TNF-related apoptosis-inducing ligand receptor 1 · TRAIL receptor 1

Resolves to

Protein
UniProtO00220UniProt nameTR10A_HUMAN
Gene
HGNCHGNC:11904NCBI Gene8797GeneCardsTNFRSF10A
Pharmacology
IUPHAR/GtoPdb1879KEGGhsa:8797
Structure
PDB5CIR
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tumor necrosis factor receptor superfamily member 10A, and which indications are they being tested in?

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