Claudin-18

BE0010573ProteinHumansCLDN18

Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). It is acted on by 12 drugs in DrugBank.

Gene name
CLDN18
UniProtKB entry
P56856Swiss-Prot
Cellular location
Cell junction, tight junction
Residues / weight
261 residues · 27,856 Da

Resolves to

Protein
UniProtP56856UniProt nameCLD18_HUMAN
Gene
HGNCHGNC:2039NCBI Gene51208GeneCardsCLDN18
Pharmacology
KEGGhsa:51208
Drugs

What you can answer from here — as of October 31, 2023

12DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Claudin-18, how selective are they, and which programs against it are still in active trials?

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