DNA-directed RNA polymerase II subunit RPB1

BE0010600ProteinHumansPOLR2A

Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). It is acted on by 3 drugs in DrugBank.

Gene name
POLR2A
UniProtKB entry
P24928Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,970 residues · 217,204 Da
Also known as
2.7.7.6 · 3'-5' exoribonuclease · DNA-directed RNA polymerase II subunit A · DNA-directed RNA polymerase III largest subunit · POLR2

Resolves to

Protein
UniProtP24928UniProt nameRPB1_HUMAN
Gene
HGNCHGNC:9187NCBI Gene5430GeneCardsPOLR2A
Pharmacology
KEGGhsa:5430
Structure
PDB2GHQPDB2GHTPDB2LTO
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase II subunit RPB1, and which indications are they being tested in?

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