Ephrin-B2

BE0010647ProteinHumansEFNB2

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It is acted on by 1 drug in DrugBank.

Gene name
EFNB2
UniProtKB entry
P52799Swiss-Prot
Cellular location
Cell membrane
Residues / weight
333 residues · 36,923 Da
Also known as
EPH-related receptor tyrosine kinase ligand 5 · EPLG5 · HTK ligand · HTK-L · HTKL

Resolves to

Protein
UniProtP52799UniProt nameEFNB2_HUMAN
Gene
HGNCHGNC:3227NCBI Gene1948GeneCardsEFNB2
Pharmacology
KEGGhsa:1948
Structure
PDB2HLEPDB2I85PDB2VSK
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ephrin-B2, and which indications are they being tested in?

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