Trophoblast glycoprotein

BE0010648ProteinHumansTPBG

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It is acted on by 2 drugs in DrugBank.

Gene name
TPBG
UniProtKB entry
Q13641Swiss-Prot
Cellular location
Cell membrane
Residues / weight
420 residues · 46,031 Da
Also known as
5T4 · 5T4 oncofetal antigen · 5T4 oncofetal trophoblast glycoprotein · 5T4 oncotrophoblast glycoprotein · M6P1

Resolves to

Protein
UniProtQ13641UniProt nameTPBG_HUMAN
Gene
HGNCHGNC:12004NCBI Gene7162GeneCardsTPBG
Pharmacology
IUPHAR/GtoPdb3009KEGGhsa:7162
Structure
PDB4CNCPDB4CNMPDB6HBY
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Trophoblast glycoprotein, and which indications are they being tested in?

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