Proenkephalin-A

BE0010659ProteinHumansPENK

Neuropeptide that competes with and mimic the effects of opiate drugs. It is acted on by 1 drug in DrugBank.

Gene name
PENK
UniProtKB entry
P01210Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen
Residues / weight
267 residues · 30,787 Da

Resolves to

Protein
UniProtP01210UniProt namePENK_HUMAN
Gene
HGNCHGNC:8831NCBI Gene5179GeneCardsPENK
Pharmacology
KEGGhsa:5179
Structure
PDB1PLWPDB1PLXPDB2LWC
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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33GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Proenkephalin-A, how selective are they, and which programs against it are still in active trials?

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